Minimum System Requirements:

500 MHz CPU
128 MB RAM
Graphic Card with 32 MB RAM
300MB HDD Space
(supported are both render methods - DirectX and OpenGL)

Some features of the game:

-Complete 3D Engine (although it's an arcade)
-5 episodes in different enviroments
-8 unique weapons
-lots of enemies (mutants,mechs,bosses)
-special power-ups (jetpack,double damage,energetic shield,...)



Source: Duke Nukem Manhattan Project [Mediafire]